---
title: Sarcopenia & MHT
description: Muscle is a power house for energy and health. Did you know you are at risk of losing it in menopause if you are not aware? Can MHT help?
image: https://media1-production-mightynetworks.imgix.net/asset/f7380996-a2a3-4c46-8976-704bec4c9aaf/Copy_of_Social_Media_Templates_v1__26_.jpg?ixlib=rails-4.2.0&fm=jpg&q=75&auto=format&w=1400&h=1400&fit=max&impolicy=ResizeCrop&constraint=downsize&aspect=fit
---

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 Nov 25, 2025 7:39:27 PM

# Sarcopenia & MHT

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## **Menopause Hormone Therapy (MHT)**

Systemic menopausal hormone therapy (MHT) is an effective treatment for alleviating symptoms caused by low estrogen and hormonal fluctuations. For women with a uterus, cycling or continuously using progesterone is essential to reduce the risk of endometrial hyperplasia and uterine cancer. There is evidence that **MHT can prevent osteoporosis** in at-risk women and **help maintain or even increase bone mineral density after menopause**. Additionally, MHT, especially when combined with strength training, can help preserve and improve muscle mass, strength, and insulin sensitivity. Explore our 'How Can I Protect My Bones' section.

A meta-analysis of RCTs examined the effects of HT on muscle mass in postmenopausal women. 

While HT appears to positively influence **muscle mass,** its effect on **muscle strength **is less clear. Some studies have reported improvements in muscle strength with HT, while others have not observed significant changes. This inconsistency indicates that more research is needed to determine the extent to which HT affects muscle strength in postmenopausal women. [jamanetwork.com](https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2749051?utm_source=chatgpt.com)

Current clinical trials continue to explore the relationship between HT and sarcopenia. One such study is evaluating sarcopenia in women at different stages of menopause, comparing those on hormone replacement therapy to those who are not, as well as to premenopausal women. This research aims to provide deeper insights into how HT may influence muscle health during menopause. [clinconnect.io](https://clinconnect.io/trials/NCT06792201?utm_source=chatgpt.com)

In terms of osteoarthritis, there is a positive link between estrogen deprivation and the frequency and severity of osteoarthritis, particularly in the knee, hip, and fingers. Although the use of MHT for preventing and treating osteoarthritis remains a topic of debate, emerging research suggests it may have a protective effect. Further studies will help clarify MHT's role in managing osteoarthritis.

**Feeling Overwhelmed? Book a one-on-one session with a PAUZ expert ([www.pauz.health](https://www.pauz.health/))**

**Resources**  
 

[Frontiers | Tissue-Specific Effects of Loss of Estrogen during Menopause and Aging](https://doi.org/10.3389/fendo.2012.00019)

Dieli-conwright cM, Spektor tM, Rice Jc, et al. influence of hormonereplacement therapy on eccentric exercise induced myogenic geneexpression in postmenopausal women. J Appl Physiol (1985).2009;107(5):1381–1388. doi: 10.1152/japplphysiol.00590.2009.

\[40\] Pöllänen e, Fey v, törmäkangas t, et al. Power training and post-menopausal hormone therapy affect transcriptional control of spe-cific co-regulated gene clusters in skeletal muscle. Age (Dordr).2010;32(3):347–363. doi: 10.1007/s11357-010-9140-1.

\[41\] taaffe DR, Newman AB, Haggerty cl, et al. estrogen replacement,muscle composition, and physical function: the health ABc study.Med Sci Sports exerc. 2005;37(10):1741–1747. doi: 10.1249/01.mss.0000181678.28092.31.

\[42\] Hansen M, Skovgaard D, Reitelseder S, et al. effects of estrogenreplacement and lower androgen status on skeletal muscle colla-gen and myofibrillar protein synthesis in postmenopausal women.J Gerontol A Biol Sci Med Sci. 2012;67(10):1005–1013.

Wells G, tugwell P, Shea B, et al. Meta-analyses of therapies forpostmenopausal osteoporosis. v. Meta-analysis of the efficacy ofhormone replacement therapy in treating and preventing osteopo-rosis in postmenopausal women. endocr Rev. 2002;23(4):529–539.doi: 10.1210/er.2001-5002.

\[56\] de villiers tJ, Pines A, Panay N, et al. Updated 2013 internationalmenopause society recommendations on menopausal hormonetherapy and preventive strategies for midlife health. climacteric.2013;16(3):316–337. doi: 10.3109/13697137.2013.795683.

\[57\] Genazzani AR, Gambacciani M, Schneider HP, et al. Postmenopausalosteoporosis: therapeutic options. climacteric. 2005;8(2):99–109.doi: 10.1080/13697130500118027.

\[58\] Rossouw Je, Anderson Gl, Prentice Rl, et al. Risks and benefits ofestrogen plus progestin in healthy postmenopausal women: prin-cipal results from the women’s health initiative randomized con-trolled trial. JAMA. 2002;288(3):321–333. doi: 10.1001/jama.288.3.321.

\[59\] torgerson DJ, Bell-Syer Se. Hormone replacement therapy and pre-vention of nonvertebral fractures: a meta-analysis of randomizedtrials. JAMA. 2001;285(22):2891–2897. doi: 10.1001/jama.285.22.2891.

\[60\] Gambacciani M, levancini M. Hormone replacement therapy andthe prevention of postmenopausal osteoporosis. Prz Menopauzalny.2014;13(4):213–220

- PMID: **39077777**
-  PMID: 24463691
-  PMID:35797481
- PMID:26444994
- doi: [Management of perimenopausal and menopausal symptoms](https://doi.org/10.1136/bmj-2022-072612) 

[Frontiers | Effect of Estrogen on Musculoskeletal Performance and Injury Risk](https://doi.org/10.3389/fphys.2018.01834)

 

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